Characteristics of lithocholic acid- versus vehicle-induced vasodilation
| Variable | Vehicle (0.1% DMSO) | Lithocholic Acid (45 μM) |
|---|---|---|
| Rise time, s | 244.2 ± 16.1 | 231.9 ± 21.9 |
| Maximal effect, % from diameter before compound application | 110.8 ± 1.6 | 116.58 ± 1.9** |
| Time for full recovery, s | 347.4 ± 47.1 | 981.4 ± 129.8** |
| Integral (area under the curve) from the time of drug application until complete washout of effect | 10,262 ± 2574 | 18,369 ± 3,964** |
| Effect remaining after ∼6 min of washout, % increase from diameter before agent application | None | 109.9 ± 1.7** |
↵** Significantly different from control, vehicle-containing solution (p < 0.01) (paired Student's t test).