Binding affinity of agonists and antagonists at A1, A2A, A2B, and A3 adenosine receptor subtypes
Ki values are shown with S.E.M. or 95% confidence intervals in parentheses.
| A1 | A2A | A2B | A3 | Reference | |
|---|---|---|---|---|---|
| NECA | 14 (6.4-29) | 20 (12-35) | 6.2 (3.5-11) | Fredholm et al., 2001 | |
| NECA | 260 ± 30 | Varani et al., 2005 | |||
| Cl-IB-MECA | 115 (114-116) | 2100 (1700-2500) | >100,000 (from a cAMP assay) | 11 (9.4-13) | Fredholm et al., 2001 |
| MRE 3008F20 | 1120 ± 130 | 165 ± 18 | 1500 ± 165 | 0.9 ± 0.1 | Varani et al., 2005 |
| MRE 2029F20 | 200 ± 25 | >1000 | 3.2 ± 0.3 | >1000 | Varani et al., 2005 |
| B64 | 708 (598-838) | 495 (402-608) | 34 (26-45) | 3.7 (3.2-4.3) | Baraldi et al., 2002 |