Enzyme | Kma or S50b | Ksi a | Hill coefficient (nH)b | Vmax c | CLintd or CLmaxe |
---|---|---|---|---|---|
μM | μM | pmol/min/mg | μl/min/mg | ||
UGT1A3 | 1205 ± 37a | 916 ± 30 | 1273 ± 41 | 1.06d | |
UGT1A3–4 | 781 ± 10a | 1931 ± 35 | 767 ± 2 | 0.98d | |
UGT1A3–4-3 | 702 ± 71a | 1496 ± 193 | 613 ± 2 | 0.87d | |
UGT1A3(I36T) | 994 ± 39b | 1.57 ± 0.06 | 115 ± 1 | 0.06e | |
UGT1A3(H40P) | 1493 ± 93b | 2.12 ± 0.15 | 15 ± 0.5 | 0.01e | |
UGT1A4 | N.A. | N.A. | N.A. | N.A. | N.A. |
UGT1A4–3 | 1012 ± 29b | 2.29 ± 0.14 | 24 ± 0.2 | 0.02e | |
UGT1A4–3-4 | 848 ± 102a | 2393 ± 160 | 87 ± 11 | 0.10d | |
UGT1A4(T36I) | 537 ± 6a | 1680 ± 32 | 98 ± 1 | 0.18d | |
UGT1A4(P40H) | N.A. | N.A. | N.A. | N.A. | N.A. |