Wild-Type Pregnant | Bcrp1−/− pregnant | Z0 | p | |
---|---|---|---|---|
Maternal plasma AUC (μg · min/ml plasma) | 55.8 ± 2.7 | 47.9 ± 2.3 | 2.27 | <0.05 |
Fetal AUC (ng · min/g fetus) | 575.6 ± 44.6 | 1108.2 ± 62.3 | 6.95 | <0.01 |
Fetal/maternal plasma AUC ratio | 10.3 | 23.2 | ||
Maternal plasma CL (ml/min) | 17.9 ± 0.9 | 20.9 ± 1.0 | 2.26 | <0.05 |
Maternal Vss (ml) | 37.9 ± 127.8 | 22.0 ± 76.1 | 0.11 | >0.05 |
Maternal MRT | 2.1 ± 7.1 | 1.1 ± 3.6 | 0.13 | >0.05 |