TABLE 2

Pharmacokinetic parameters of FEX during constant intravenous infusion into FVB mice (n = 5) and Mrp2−/− mice (n = 6)

Data represent the mean ± S.E. (n = 5 or 6). The meanings of these parameters are explained under Materials and Methods.

Parameters FVB Mice (n = 5) Mrp2−/− Mice (n = 6)
Css (nM)a 414 ± 54 597 ± 49*
CLtot,plasma (ml/min/kg b.wt.) 29.8 ± 3.9 20.1 ± 1.4*
CLbile,plasma (ml/min/kg b.wt.) 9.48 ± 0.82 3.38 ± 0.38**
CLbile,liver (ml/min/kg b.wt.) 0.250 ± 0.053 0.198 ± 0.022
Vbile (nmol/min/kg b.wt.) 3.71 ± 0.32 1.93 ± 0.14**
Bile flow rate (μl/min/kg b.wt.) 64.0 ± 7.1 53.1 ± 4.6
K p,liver 40.7 ± 6.8 16.2 ± 2.0*
CLurine,p (ml/min/kg b.wt.) 16.9 ± 2.3 15.2 ± 3.2
Vurine (nmol/min/kg b.wt.) 6.59 ± 0.91 8.66 ± 1.79
GFR (ml/min/kg b.wt.) 17.3 ± 0.9 17.7 ± 2.5
K p,kidney 22.7 ± 4.4 21.8 ± 3.1
K p,brain 0.0183 ± 0.0028 0.0190 ± 0.0043

  • GFR, glomerular filtration rate.

  • ↵ a Corrected steady-state plasma concentration at the infusion rate of 700 nmol/h/kg.

  • ↵* p < 0.05

  • ↵** p < 0.01.