TABLE 3

Pharmacokinetic parameters of FEX during constant intravenous infusion into FVB mice (n = 7) and Mrp3−/− mice (n = 6)

Data represent the mean ± S.E. (n = 6 or 7). The meanings of these parameters are explained under Materials and Methods.

Parameters FVB Mice (n = 7) Mrp3−/− Mice (n = 6)
Css (nM)a 382 ± 46 214 ± 11**
CLtot,plasma (ml/min/kg b.wt.) 33.6 ± 3.8 56.1 ± 3.1**
CLbile,plasma (ml/min/kg b.wt.) 9.32 ± 1.01 25.9 ± 1.1**
CLbile,liver (ml/min/kg b.wt.) 0.235 ± 0.025 0.495 ± 0.023**
Vbile (nmol/min/kg b.wt.) 3.17 ± 0.27 5.64 ± 0.19**
Bile flow rate (μl/min/kg b.wt.) 53.7 ± 3.4 88.6 ± 7.4*
K p,liver 37.9 ± 3.4 48.0 ± 2.1*
CLurine,p (ml/min/kg b.wt.) 14.2 ± 2.3 19.0 ± 1.8
Vurine (nmol/min/kg b.wt.) 4.84 ± 0.91 4.11 ± 0.30
GFR (ml/min/kg b.wt.) 15.1 ± 2.1 19.9 ± 1.8
K p,kidney 23.5 ± 2.3 24.8 ± 2.1
K p,brain 0.0169 ± 0.0016 0.0171 ± 0.0021
  • GFR, glomerular filtration rate.

  • a Corrected steady-state plasma concentration at the infusion rate of 700 nmol/h/kg.

  • * p < 0.05

  • ** p < 0.01.