TABLE 4

Pharmacokinetic parameters of FEX during constant intravenous infusion into C57BL/6 mice (n = 4) and Mrp4−/− mice (n = 3)

Data represent the mean ± S.E. (n = 3 or 4). The meanings of these parameters are explained under Materials and Methods.

Parameters C57BL/6 Mice (n = 4) Mrp4−/− Mice (n = 3)
Css (nM)a 480 ± 49 382 ± 29
CLtot,plasma (ml/min/kg b.wt.) 25.5 ± 2.9 31.1 ± 2.2
CLbile,plasma (ml/min/kg b.wt.) 10.9 ± 1.5 15.3 ± 1.1
CLbile,liver (ml/min/kg b.wt.) 0.369 ± 0.033 0.454 ± 0.025
Vbile (nmol/min/kg b.wt.) 5.50 ± 0.26 5.50 ± 0.18
Bile flow rate (μl/min/kg b.wt.) 71.1 ± 11.1 76.6 ± 2.2
K p,liver 28.3 ± 3.7 29.5 ± 0.4
CLurine,p (ml/min/kg b.wt.) 14.7 ± 1.3 17.2 ± 3.1
Vurine (nmol/min/kg b.wt.) 7.69 ± 0.80 6.13 ± 0.85
GFR (ml/min/kg b.wt.) 13.6 ± 1.2 12.8 ± 2.4
K p,kidney 15.6 ± 1.5 15.6 ± 1.7
K p,brain 0.0210 ± 0.0015 0.0210 ± 0.0021
  • GFR, glomerular filtration rate.

    *p < 0.05

    **p < 0.01.

  • a Corrected steady-state plasma concentration at the infusion rate of 700 nmol/h/kg.