TABLE 3

Cathepsin C EOA and granzyme B inhibition IC50 in TALL-104 cells

Data ± S.E.M. values are indicated for all compounds tested in at least three independent assays. The average IC50 for each compound was calculated by averaging single IC50 values obtained in individual experiments.



Cell-Based Potency

Ratio gB Act./EOA
Compound
Cathepsin C EOA
gB Activation
μM
1 0.89 ± 0.15 2.45 ± 0.37 2.9
2 0.75 (n = 2) 2.75 ± 0.26 3.7
3 11.0 13.8 (n = 2) 1.3
4 >50 38 (n = 2) N.A.
5 >50 >50 N.A.
6 0.55 2.42 4.4
7
29.0
41 (n = 2)
1.4
  • N.A., not available.