Pharmacokinetic analysis of intravenous bolus ciprofloxacin in wild-type and Oat3(−/−) mice Ciprofloxacin was administered by intravenous bolus injection at a 5 mg/kg dose, and serial plasma samples were analyzed (see Fig. 6). Noncompartmental pharmacokinetic analysis was performed. Data are shown as mean ± S.E. Plasma clearance was calculated using the AUC from zero to infinity.
Sex | Genotype | Pharmacokinetic Parameter | ||||||
|---|---|---|---|---|---|---|---|---|
| Vdss | Half-Life | AUC | Plasma Clearance | |||||
| ml/kg | min | min·ng/μl | ml/min/kg | |||||
| Male | Wild type (n = 4) | 2391 ± 141 | 35.3 ± 2.6 | 47.9 ± 2.5 | 49.5 ± 3.3 | |||
| Oat3(−/−) (n = 6) | 1755 ± 107** | 30.8 ± 6.1 | 60.0 ± 2.7* | 47.9 ± 7.0 | ||||
| Female | Wild type (n = 3) | 1949 ± 66† | 21.2 ± 1.0†† | 47.3 ± 1.4 | 69.0 ± 2.8†† | |||
|
| Oat3(−/−) (n = 5) | 1673 ± 13** | 28.7 ± 2.9 | 62.8 ± 2.2** | 44.9 ± 3.0** | |||
*, P < 0.05; **, P < 0.01, significant differences for Oat3(−/−) compared with wild type for the same sex.
†, P < 0.05; ††, P < 0.01, significant differences for female compared with male for the same genotype.