Expression of hepatic drug transporters in mouse liver comparing wild-type and Slco1b2-knockout animals.
Data are presented as mean expression relative to wild-type male animals ± S.D.
Wild-Type | Slco1b2(−/−) | |||||
|---|---|---|---|---|---|---|
| Female | Male | Female | Male | |||
| Abcc2 | 1.36 ± 0.56 | 1.01 ± 0.14 | 1.71 ± 0.58 | 0.90 ± 0.45 | ||
| Abcc3 | 1.99 ± 0.60 | 1.08 ± 0.36 | 2.83 ± 1.19 | 1.53 ± 0.35 | ||
| Abcc4 | 1.67 ± 0.29 | 1.03 ± 0.25 | 3.03 ± 0.47* | 1.51 ± 0.63 | ||
| Abcg2 | 0.32 ± 0.06 | 1.01 ± 0.15 | 0.47 ± 0.14 | 1.11 ± 0.22 | ||
| Ostα | 1.05 ± 0.42 | 1.10 ± 0.47 | 1.94 ± 3.47 | 2.89 ± 3.47 | ||
| Ostβ | 3.65 ± 1.04 | 1.03 ± 0.29 | 3.61 ± 2.24 | 0.62 ± 0.18* | ||
| Abcb11 | 0.71 ± 0.19 | 1.05 ± 0.33 | 0.98 ± 0.18* | 0.79 ± 0.37 | ||
| Slc10a1 | 3.04 ± 1.51 | 1.20 ± 0.62 | 4.18 ± 3.93 | 1.87 ± 2.00 | ||
| Abcb1b | 0.41 ± 0.09 | 1.03 ± 0.26 | 0.75 ± 0.35 | 1.94 ± 0.35 | ||
|
Slc22a7
| 1.76 ± 0.71 | 1.01 ± 0.12 | 1.16 ± 0.42* | 0.75 ± 0.08 | ||
↵* p < 0.05