Receptor Subtype | Mode of Expression | a | EC50H | nH1 | 1 - a | EC50L | nH2 | n |
---|---|---|---|---|---|---|---|---|
μM | μM | |||||||
Control (α1β2) | Homozygote | 25 ± 2 | 5.8 ± 0.8 | 1.0 ± 0.05 | 75 | 63.9 ± 7.2 | 1.4 ± 0.05 | 45 |
β2-L301V | Homozygote | 63 ± 1* | 0.9 ± 0.2* | 1.5 ± 0.14 | 37* | 18.8 ± 2.8* | 0.8 ± 0.02 | 6 |
Heterozygote | 56 ± 3* | 3.8 ± 1.2* | 1.3 ± 0.06 | 44* | 41.2 ± 6.7 | 0.9 ± 0.05 | 22 | |
β2-L308A | Homozygote | 57 ± 8* | 0.5 ± 0.1* | 1.8 ± 0.10 | 43* | 21.0 ± 3.8* | 1.4 ± 0.2 | 10 |
Heterozygote | 53 ± 4* | 1.6 ± 0.3* | 1.4 ± 0.09 | 47* | 37.4 ± 2.1 | 1.3 ± 0.07 | 13 | |
β2-L287M | Homozygote | 79 ± 2* | 0.3 ± 0.0* | 1.6 ± 0.15 | 21* | 2.9 ± 0.9* | 1.9 ± 0.15 | 7 |
| Heterozygote | 65 ± 3* | 0.4 ± 0.1* | 1.6 ± 0.13 | 35* | 5.3 ± 2.3* | 1.0 ± 0.05 | 7 |
↵* Significantly different from the corresponding control values, P > 0.05.