Not Pretreated | 30 min | 60 min | 120 min | 240 min | Pretreatment | ||
---|---|---|---|---|---|---|---|
pEC50 | |||||||
DAMGO | 7.70 ± 0.14 (4) | 7.13 ± 0.10 (4)* | 7.16 ± 0.09 (4)* | 7.16 ± 0.04 (4)* | 7.24 ± 0.04 (4)* | DAMGO 10 μM | |
Morphine | 7.73 ± 0.05 (3) | 7.56 ± 0.09 (3) | 7.50 ± 0.17 (3) | 7.62 ± 0.13 (3) | 7.53 ± 0.04 (3) | Morphine 10 μM | |
% Not pretreated Emax | |||||||
DAMGO | 100 | 93.21 ± 3.07 (4) | 90.10 ± 4.28 (4) | 91.72 ± 4.98 (4) | 88.47 ± 3.10 (4) | DAMGO 10 μM | |
Morphine | 100 | 99.97 ± 1.90 (3) | 102.48 ± 7.36 (3) | 103.28 ± 5.70 (3) | 92.43 ± 4.24 (3) | Morphine 10 μM |
↵* Different from not treated. P < 0.05 by Dunnett's post hoc test analysis of variance.