TABLE 1

Coefficients for the best fits of α7 wild type, Chim I, and Chim II


Receptor Type

CT

30 μM IVM

1 mM 5-HI

10 μM NS-1738

10 μM PNU-120596
EC50
nH
EC50
nH
EC50
nH
EC50
nH
EC50
nH
μM μM μM μM μM
α7 146 ± 11 1.7 ± 0.06 18.7 ± 1.3 1.4 ± 0.16 72 ± 21 1.97 ± 0.34 34 ± 7 2.06 ± 0.35 12 ± 9 1.2 ± 0.06
n = 5 n = 3 n = 3 n = 5 n = 4
Chim I 71 ± 10 1.35 ± 0.14 78 ± 6.3 1.2 ± 0.05 76 ± 6.9 1.4 ± 0.13 6 ± 1.5 1.5 ± 0.08 64.7 ± 6.8 1.2 ± 0.1
n = 4 n = 3 n = 3 n = 3 n = 3
Chim IIa 22 ± 1.6 1 ± 0.04 17.8 ± 2.4 1.1 ± 0.12 8 ± 3 1.35 ± 0.25 1.6 ± 0.8 0.71 ± 0.06 18.8 ± 6.8 0.94 ± 0.02

n = 4

n = 4

n = 4

n = 4

n = 4

  • CT, control.

  • a A concentration of 1 μM PNU-120596 was used for chimera II (Chim II)