Potentiation of responses to high agonist concentrations
The first column shows the constructs injected. The second column shows the potentiation ratio for responses to 1 mM GABA produced by 1 μM 3α5αPOH. The second column shows data for responses to 1 mM P4S. Note that for this table, potentiation of all responses has been averaged, rather than only for control responses below a criterion (see Results). Values shown are mean ± S.E., with the number of oocyte in parentheses, probability for a significant difference from βα γβα, and probability that the potentiation ratio is significantly different from 1 (that is, no effect). Comparisons among groups have a Dunnett correction after ANOVA to correct for multiple comparisons. Individual values are shown when only two oocytes were studied.
Constructs | 1 mM GABA + 1 μM 3α5αPOH | 1 mM P4S + 1 μM 3α5αPOH |
|---|---|---|
| βα γβα | 1.05 ± 0.04 (5)—ns | 9.52 ± 1.44 (6)—** |
| βα γβαL | 0.86 ± 1.01 (2) | 6.34 ± 0.89 (6)*** |
| βαL γβα | 1.04 ± 1.06 (2) | 4.78 ± 0.77 (6)***** |
| βαL γβαL | 0.73 ± 1.01 (2) | 1.51 ± 0.23 (7)*** ns |
| βα γβαW | 0.92 ± 0.02 (4) ns* | 2.59 ± 0.28 (6)***** |
| βαW γβα | 1.00 ± 0.02 (4) ns ns | 1.60 ± 0.09 (7)****** |
| βαW γβαW | 0.94 ± 0.02 (5) ns* | 0.98 ± 0.01 (8)*** ns |