TABLE 3

Potentiation of responses to a low concentration of GABA

The columns show the potentiation ratio produced by co-application of 1 μM steroid. The means are computed for control responses producing less than 0.11 of the maximal response from that oocyte (see Results and Figures 3, 4 and 5). Values shown are mean ± S.E., with the number of oocyte in parentheses, probability for a significant difference from βα γβα, and probability that the potentiation ratio is significantly different from 1 (that is, no effect). Comparisons among groups have a Dunnett correction after ANOVA to correct for multiple comparisons. Individual value shown when only one oocyte had a control fractional response less than 0.11 (see Supplementary Figure 2).


Constructs

3α5αPOH

3α5βPOH

3α5αP
βα γβα 6.26 ± 0.53 (27)—*** 3.85 ± 0.60 (6)—** 10.98 ± 1.64 (15)—***
βα γβαL 6.16 ± 0.75 (17) ns*** 3.43 ± 0.29 (6) ns*** 5.68 (1)
βαL γβα 3.40 ± 0.33 (13)****** 2.08 ± 0.11 (5)****** 3.32 ± 0.29 (4)***
βαL γβαL 1.13 ± 0.06 (18)**** 1.09 ± 0.08 (7)*** ns 1.13 ± 0.09 (6)** ns
βα γβαW 2.99 ± 0.30 (11)****** 1.86 ± 0.13 (6)*****
βαW γβα 2.14 ± 0.08 (12)****** 1.49 ± 0.03 (8)******
βαW γβαW
1.01 ± 0.05 (11)*** ns
0.81 ± 0.04 (8)*****

  • —, not applicable; ns, P > 0.05.

  • * P < 0.05.

  • ** P < 0.01.

  • *** P < 0.001.