Potentiation of responses to a low concentration of GABA
The columns show the potentiation ratio produced by co-application of 1 μM steroid. The means are computed for control responses producing less than 0.11 of the maximal response from that oocyte (see Results and Figures 3, 4 and 5). Values shown are mean ± S.E., with the number of oocyte in parentheses, probability for a significant difference from βα γβα, and probability that the potentiation ratio is significantly different from 1 (that is, no effect). Comparisons among groups have a Dunnett correction after ANOVA to correct for multiple comparisons. Individual value shown when only one oocyte had a control fractional response less than 0.11 (see Supplementary Figure 2).
Constructs | 3α5αPOH | 3α5βPOH | 3α5αP |
---|---|---|---|
βα γβα | 6.26 ± 0.53 (27)—*** | 3.85 ± 0.60 (6)—** | 10.98 ± 1.64 (15)—*** |
βα γβαL | 6.16 ± 0.75 (17) ns*** | 3.43 ± 0.29 (6) ns*** | 5.68 (1) |
βαL γβα | 3.40 ± 0.33 (13)****** | 2.08 ± 0.11 (5)****** | 3.32 ± 0.29 (4)*** |
βαL γβαL | 1.13 ± 0.06 (18)**** | 1.09 ± 0.08 (7)*** ns | 1.13 ± 0.09 (6)** ns |
βα γβαW | 2.99 ± 0.30 (11)****** | 1.86 ± 0.13 (6)***** | — |
βαW γβα | 2.14 ± 0.08 (12)****** | 1.49 ± 0.03 (8)****** | — |
βαW γβαW | 1.01 ± 0.05 (11)*** ns | 0.81 ± 0.04 (8)***** | — |