Average amplitude of potentiated responses to 1 mM P4S
The average fractional activation for responses to 1 mM P4S plus 1 μM 3α5αPOH are shown. Note that the Q241L mutation progressively reduces the average fractional activation, whereas the Q241W mutation results in relatively constant overall levels of activation. Values shown are mean ± S.E. with the number of oocyte in parentheses.
Constructs | 1 mM P4S + 1 μM 3α5αPOH |
|---|---|
| βα γβα | 0.32 ± 0.05 (6) |
| βα γβαL | 0.26 ± 0.05 (6) |
| βαL γβα | 0.07 ± 0.02 (6) |
| βαL γβαL | 0.02 ± 0.00 (7) |
| βα γβαW | 0.29 ± 0.04 (6) |
| βαW γβα | 0.25 ± 0.03 (7) |
| βαW γβαW | 0.44 ± 0.05 (8) |