TABLE 3

Pharmacokinetic parameters of metformin and Ccr in Mate1(+/+) and Mate1(−/−) mice

The CLren of metformin was obtained by dividing the amounts of metformin eliminated into urine during 60 min by the AUC0-60. The CLsec of metformin was calculated by subtracting Ccr from CLren, assuming that the protein binding of metformin in plasma is negligible. The CLnr of metformin was calculated by subtracting CLren from CLtot. Each value represents the mean ± S.D. for six mice.


Parameter

+/+

−/−
AUC0-60 (μg · min/ml) 108.7 ± 17.0 257.2 ± 39.6***
AUC (μg · min/ml) 126.3 ± 23.3 525.7 ± 152.4**
CLtot (mL/min/kg) 40.7 ± 7.0 10.2 ± 2.7***
CLren (mL/min/kg) 37.2 ± 8.5 6.6 ± 1.3***
CLnr (mL/min/kg) 3.5 ± 5.3 3.6 ± 2.0
CLsec (mL/min/kg) 31.8 ± 7.3 4.3 ± 1.2***
Q (mL/min/kg) 70.6 ± 22.5 59.5 ± 9.1
V1 (mL/kg) 392 ± 62 334 ± 88
Vdss (mL/kg) 994 ± 192 853 ± 245
Ccr (mL/min/kg)
5.4 ± 2.9
2.2 ± 0.8*
  • * P < 0.05, significantly different from Mate1(+/+) mice.

  • ** P < 0.01, significantly different from Mate1(+/+) mice.

  • *** P < 0.001, significantly different from Mate1(+/+) mice.