Sprouty proteins in the etiology of several diseases and disorders
Reports of down- and up-regulated Spry levels in different diseases are listed, including type of disease and Spry isoform(s) along with appropriate references.
| Disease | Isoforms | Reference |
|---|---|---|
| Down-regulated spry levels | ||
| Hepatocellular carcinoma | Spry2 | Fong et al., 2006; Lee et al., 2008 |
| Breast cancer | Spry1, -2 | Lo et al., 2004 |
| Prostate cancer | Spry1 | Kwabi-Addo et al., 2004 |
| Spry2 | McKie et al., 2005 | |
| Spry4 | Wang et al., 2006 | |
| Spry1, -2 | Fritzsche et al., 2006 | |
| Non–small-cell lung cancer | Spry2 | Sutterlüty et al., 2007 |
| Spry4 | ||
| Schizophrenia/bipolar disorder | Spry2 | Pillai, 2008 |
| Cardiovascular disease | Spry1 | Thum et al., 2008 |
| Spry2 | Sayed et al., 2008 | |
| Up-regulated spry levels | ||
| Melanoma (B-Raf and N-Ras mutated cell lines) | Spry2 | Bloethner et al., 2005 |
| TDII thanatophoric dysplasia II | Spry2 | Guo et al., 2008 |