ABCG2 genetic variants in the NCI-60 cell lines
Genotyping of ABCG2 was performed as described under Materials and Methods.
| Nucleotide Change | Amino Acid | Reference Sequence | Cell Lines | |
|---|---|---|---|---|
| Heterozygote Variants | Homozygote Variants | |||
| Intron 1 | rs2622604 | MOLT4, HOP-92, HCC2998, SF539, SNB19, SNB75, U251, SKMEL5, OVCAR3, OVCAR8, RXF393, TK10, NCI ADR-RES, MDA-MB-231, HS578T, 786−0 | SW620, OVCAR 5, BT549, T47D | |
| 914C>A | Q141K | rs2231142 | A549, COLO205, HCT116, SF295, MALME-3M, SK-OV-3, CAKI-1, HOP62, HOP92, MDA-MB-231 | LOX IMVI, A498 |
| 862C>T | Y123Y | rs2231139 | None | None |
| 989C>G | Q166E | rs1061017 | None | None |
| 1057A>G | G188G | rs3116439 | None | None |
| 1116T>C | F208S | rs1061018 | None | None |
| 1235T>C | S248P | rs3116448 | None | None |
| 1493G>T | E334* | rs3201997 | None | None |