TABLE 1

Binding affinity and the relative transactivation potency of selected skin active ERβ ligands

Data were extracted mainly from recent publications (Malamas et al., 2004; Harris, 2007) and confirmed with our unpublished internal testing.

ER Binding AffinityER Transactivation Assay (EC50)Base Structure
ERβERαRatioERβERα
nMnM
17β-Estradiol22193
WAY-2000702.31556831314Benzoxazole
ERB-0415.41216226290>3000Benzoxazole