TABLE 1

RGS4/Gαo TR-FRET high-throughput screening results

Actives were determined as follows: primary screen, >2 SD from the negative control; TR-FRET DRC, IC50 value <400 μM; FCPIA DRC: IC50 value <500 μM.

AssayCompounds TestedActiveHit Rate
%
ChemDiv Library Subset43,8781620.37
TR-FRET DRC114110.025
FCPIA DRC1120.0046