EC50 | nH | R(Taurine/Gly) | n | |
---|---|---|---|---|
μM | ||||
159-Phe (WT) | 507 ± 29 | 2.1 ± 0.3 | 1.0 ± 0.05 | 5 |
159-F-Phe | 681 ± 56 | 2.1 ± 0.2 | 0.7 ± 0.04 | 5 |
159-CN-Phe | 5100 ± 458* | 1.4 ± 0.1 | 0.7 ± 0.04 | 5 |
159-F3-Phe | 9700 ± 2400* | 1.9 ± 0.4 | 0.03 ± 0.005 | 5 |
207-F-Phe | 720 ± 89 | 1.2 ± 0.4 | 0.6 ± 0.10 | 6 |
207-F2-Phe | 5600 ± 430* | 0.8 ± 0.2 | 0.03 ± 0.005 | 3 |
207-F3-Phe | 3600 ± 230* | 0.7 ± 0.4 | 0.004 ± 0.001 | 4 |
63-F-Phe | 389 ± 41 | 1.2 ± 0.1 | 0.6 ± 0.03 | 6 |
63-F2-Phe | N.R. | 8 | ||
161-F-Phe | 2500 ± 200* | 1.6 ± 0.2 | 0.6 ± 0.03 | 6 |
161-CN-Phe | 423 ± 14 | 1.4 ± 0.1 | 0.7 ± 0.04 | 7 |
N.R., no response at 100 mM.
↵* P < 0.05, significantly different from WT for EC50 values (Student's t test).