TABLE 2

Potency and maximal response indices for potentiation by mGlu5 receptor PAMs of [³H]IP_x accumulations stimulated by an EC₂₀ concentration (50 nM) of the orthosteric agonist quisqualate in astrocytes

pEC₅₀ values are given as −log (molar) values, and maximum potentiation values are given as a fold increase in [³H]IP_x accumulation compared with the response stimulated in the presence of 50 nM quisqualate alone. Data are shown as means ± S.E.M. for four to five separate experiments each performed in duplicate. Also shown are equilibrium dissociation constants (pK_B) and net cooperativity (αβ) with respect to quisqualate; the efficacy cooperativity (β) is estimated by dividing the overall cooperativity (αβ) by the affinity cooperativity (α; Table 1).