pEC50 | ||||
---|---|---|---|---|
Wild Type | Met149 | |||
Peptide | + 3 μM Compound 2 | Peptide | + 3 μM Compound 2 | |
GLP-1(7–36)NH2 | 10.2 ± 0.3 | 10.8 ± 0.6 | 7.0 ± 0.2 | 9.7 ± 0.8* |
Exendin-4 | 10.4 ± 0.2 | 10.8 ± 0.6 | 8.5 ± 0.2 | 9.6 ± 0.7† |
Oxyntomodulin | 8.9 ± 0.2 | 9.8 ± 1.0† | N.D. | N.D. |
N.D., data unable to be experimentally defined or with incomplete curves.
* Statistically significant, P < 0.05 compared with peptide control, paired t test.
† P = 0.05 compared with peptide control, paired t test.