TABLE 2

Pharmacokinetic parameters of triazolam for different doses of rifampicin, sulfinpyrazone, and pioglitazone in huPXR/huCAR/huCYP3A4/3A7 mice

huPXR/huCAR/huCYP3A4/3A7 mice were given different oral doses of RIF, SUL, or PIO followed by a 5 mg/kg oral dose of TRZ. Data represent the mean ± S.D. (n = 3 mice per compound and treatment). The TRZ C_max and AUC values from mice treated with RIF, SUL, or PIO were compared with those from the corresponding vehicle-treated control group with a one-way analysis of variance with Dunnett test.

Dose	TRZ
Dose	t_max	C_max	t_1/2	AUC_0-∞	AUC Decrease
	h	ng/ml	h	ng · h⁻¹ · ml⁻¹	%
Rifampicin
0 mg/kg	1.0 ± 0.0	730 ± 341	1.26 ± 0.38	1680 ± 580
1 mg/kg	0.5 ± 0.0	464 ± 181	1.01 ± 0.17	814 ± 356	52
3 mg/kg	0.5 ± 0.0	337 ± 131	1.49 ± 0.27	615 ± 315^*	63
10 mg/kg	0.5 ± 0.0	113 ± 23^*	1.23 ± 0.22	156 ± 11^**	91
Sulfinpyrazone
0 mg/kg	0.5 ± 0.0	484 ± 93	1.39 ± 0.31	1200 ± 240
0.5 mg/kg	0.7 ± 0.3	467 ± 109	1.46 ± 0.31	1190 ± 180	1
2 mg/kg	0.5 ± 0.0	447 ± 104	1.28 ± 0.25	1020 ± 230	15
10 mg/kg	0.5 ± 0.0	351 ± 49	1.43 ± 0.26	756 ± 71^*	37
Pioglitazone
0 mg/kg	0.7 ± 0.3	624 ± 124	1.31 ± 0.31	1420 ± 240	—
2 mg/kg	0.5 ± 0.0	653 ± 163	1.15 ± 0.12	1390 ± 340	2
10 mg/kg	0.8 ± 0.3	767 ± 176	1.06 ± 0.03	1420 ± 390	0
50 mg/kg	0.5 ± 0.0	906 ± 90	1.20 ± 0.17	1890 ± 450	-33

* P < 0.05, significantly different from control.
** P < 0.01, significantly different from control.