TABLE 2

Bias factors for ligands at the AT_1AR

The column “Bias” denotes whether a statistically significant difference in bias compared to the reference balanced agonist angiotensin II is present (either toward G protein or β-arrestin), whereas “Non” denotes an insignificant difference from the balanced agonist.

Ligand	Equiactive			Operational Model
Ligand	β	S.E.M._β	Bias	σ_IP1	S.E.M._σIP1	σ_βarr	S.E.M._σβarr	β	S.E.M._β	Bias
AngII	0.000	0.093	Non	0.000	0.126	0.000	0.121	0.000	0.174	Non
TRV120026	−2.342	0.938	Non	−1.983	0.188	−0.290	0.107	−1.197	0.217	βarr
TRV120055	−0.029	0.119	Non	1.582	0.111	1.010	0.120	0.404	0.163	Non
TRV120056	−0.007	0.119	Non	1.119	0.111	0.510	0.119	0.431	0.163	Non
TRV120044	−2.122	2.308	Non	−2.343	0.376	−0.223	0.106	−1.500	0.390	βarr
TRV120045	−1.812	1.189	Non	−2.202	0.273	−0.118	0.111	−1.474	0.295	βarr
TRV120034	−1.349	0.582	Non	−1.892	0.166	−0.105	0.112	−1.264	0.201	βarr
S1C4	0.195	0.133	Non	0.594	0.113	−0.306	0.105	0.636	0.154	Non
SGG	−1.237	0.282	βarr	−1.634	0.141	−0.271	0.106	−0.964	0.176	βarr
A1	−0.089	0.120	Non	−0.312	0.126	−0.126	0.118	−0.131	0.173	Non

β, bias factor; σ, effective signaling.