Affinity (pKd or pKi) of CXCR2 ligands at various CXCR2 orthologs
Displacement of 125I-CXCL8 binding to COS-7 cell membranes expressing indicated CXCR2 orthologs. The data are presented as mean ± S.E.M. of at least three independent experiments.
| CXCR2 | pKd CXCL8 | pKi | |
|---|---|---|---|
| SB265610 | Compound 1 | ||
| Rhesus monkey | 9.55 ± 0.19 | 7.71 ± 0.16 | <4 |
| Cynomolgus monkey | 9.21 ± 0.05 | 7.44 ± 0.05 | <4 |
| Vervet | 9.31 ± 0.18 | 7.71 ± 0.11 | <4 |
| Baboon | 9.33 ± 0.08 | 7.28 ± 0.10 | <4 |
| Human | 9.40 ± 0.14 | 7.68 ± 0.11 | 7.18 ± 0.13 |
| Chimpanzee | 9.29 ± 0.18 | 7.72 ± 0.17 | 6.81 ± 0.18 |
| Gorilla | 9.33 ± 0.03 | 7.70 ± 0.12 | 6.90 ± 0.10 |
| Orangutan | 9.12 ± 0.15 | 7.42 ± 0.07 | 6.38 ± 0.16 |