TABLE 1
Antagonist and ConcentrationEROD Activity (Percentage of 10 nM TCDD)
HaCaTHepG2T84
%%%
CH223191
    1 μM33 ± 658 ± 1630 ± 8
CHD-5
    1 μM27 ± 658 ± 1329 ± 8
    10 μM21 ± 1128 ± 928 ± 9
CHD-7
    1 μM104 ± 10*82 ± 994 ± 9*
    10 μM96 ± 498 ± 1668 ± 3
CHD-8
    1 μM113 ± 4*68 ± 7103 + 9*
    10 μM109 ± 979 ± 787 ± 2*
CHD-11
    1 μM36 ± 1033 ± 1032 ± 7
    10 μM23 ± 329 ± 928 ± 9
CHD-12
    1 μM29 ± 734 + 831 ± 8
    10 μM21 ± 229 + 924 ± 10
  • * Statistically different (P < 0.05) from CH223191.

  • Statistically different (P < 0.05) from CHD-5, CHD-11, and CHD-12 at the corresponding concentrations.

  • Statistically different (P < 0.05) from CHD-11 and CHD-12 at the corresponding concentrations.