TABLE 2
Affinity (pKd or pKi) of CXCR2 ligands at human-baboon chimeras
Displacement of 125I-CXCL8 binding to COS-7 cell membranes expressing indicated chimeric receptors HHB, BBH, HBB, BHH, HBH, and BHB. The data are presented as mean ± S.E.M. of at least three independent experiments.
| CXCR2 | pKd CXCL8 | pKi | ||
|---|---|---|---|---|
| SB265610 | Compound 1 | |||
 | Human | 9.40 ± 0.14 | 7.68 ± 0.11 | 7.18 ± 0.13 |
 | Baboon | 9.33 ± 0.08 | 7.28 ± 0.10 | <4 |
 | HHB chimera | — | — | — |
 | BBH chimera | 9.41 ± 0.21 | 7.17 ± 0.19 | 6.70 ± 0.10 |
 | HBB chimera | — | — | — |
 | BHH chimera | 9.52 ± 0.09 | 6.93 ± 0.20 | 6.66 ± 0.11 |
 | HBH chimera | 9.49 ± 0.11 | 7.33 ± 0.16 | 6.90 ± 0.10 |
 | BHB chimera | 9.43 ± 0.07 | 7.20 ± 0.04 | <4 |
—, 125I-CXCL8 does not bind to this construct.