Agonist-induced desensitization of MOPr-activated GIRK current in LC neurons
The desensitization-phase data for a saturating concentration of each agonist from a number of experiments (Fig. 2B) were fitted to a one-phase, exponential-decay model, to obtain values for t1/2 and the extent of desensitization (plateau). Values shown are means and 95% confidence intervals.
| Agonist | t1/2 (95% CI) | Extent of Desensitization (95% CI) |
|---|---|---|
| min | % | |
| Endomorphin-2 (30 μM) | 1.58 (1.52–1.64) | 47.9 (47.4–48.4) |
| DAMGO (10 μM) | 2.98 (2.76–3.23) | 52.7 (51.1–54.3) |
| Etorphine (1 μM) | 5.04 (4.10–6.55) | 54.6 (47.4–61.8) |
| Morphine (30 μM) | 3.38 (3.16–3.63) | 30.2 (29.1–31.3) |
CI, confidence interval.