TABLE 2

Effect of a fixed concentration of cilomilast, roflumilast, or formoterol on the E/[A] relationship that describes FP-induced, GRE-dependent transcription in 2×GRE BEAS-2B reporter cells

Data are derived from the graphs in Fig. 1, A and B, and were analyzed by one-way analysis of variance followed by Tukey’s multiple comparison test.

Treatment	N	p[A]₅₀ of FP	E_max of FP	Enhancement of Maximum FP-Induced Response
		M	Fold	Fold
FP	16	−8.51 ± 0.09	18.0 ± 0.9	1
+ Cilomilast (10 µM)	9	−8.35 ± 0.07	34.9 ± 1.9^*	1.9
+ Roflumilast (1 µM)	12	−8.29 ± 0.10	28.6 ± 1.1^*	1.6
+ Formoterol (1 nM)	12	−8.37 ± 0.03	41.4 ± 1.2^*	2.3

↵* P < 0.05, E_max significantly different from that produced by FP alone.