TABLE 2

Effect of a fixed concentration of cilomilast, roflumilast, or formoterol on the E/[A] relationship that describes FP-induced, GRE-dependent transcription in 2×GRE BEAS-2B reporter cells

Data are derived from the graphs in Fig. 1, A and B, and were analyzed by one-way analysis of variance followed by Tukey’s multiple comparison test.

TreatmentNp[A]50 of FPEmax of FPEnhancement of Maximum FP-Induced Response
MFoldFold
FP16−8.51 ± 0.0918.0 ± 0.91
+ Cilomilast (10 µM)9−8.35 ± 0.0734.9 ± 1.9*1.9
+ Roflumilast (1 µM)12−8.29 ± 0.1028.6 ± 1.1*1.6
+ Formoterol (1 nM)12−8.37 ± 0.0341.4 ± 1.2*2.3
  • * P < 0.05, Emax significantly different from that produced by FP alone.