TABLE 6

BRET arrestin affinity and potency values

CompoundEC50Emax
nM
Salvinorin A5.55 (−8.25 ± 0.05)98.84
GR898960.265 (−9.58 ± 0.03)104
ICI 199,4410.461 (−9.34 ± 0.07)100
U6206619.8 (−7.70 ± 0.07)101
RB 64118 (−6.93 ± 0.06)105
RB 4845.0 (−7.35 ± 0.06)101
RB 55196 (−6.71 ± 0.03)78.9
RB 593560 (−5.44 ± 0.18)177
Dyn 1–1378.2 (−7.11 ± 0.13)86.3
Dyn 1–11132 (−6.87 ± 0.16)86.9
Dyn 1–9253 (−6.59 ± 0.11)92.8
Dyn 1–81070 (−5.97 ± 0.11)102
Dynorphin A112 (−6.95 ± 0.13)99.2