TABLE 4

Affinity and potency values for benzomorphans using GloSensor and Tango assays

BenzomorphansG Protein EC50G Protein EmaxArrestin EC50Arrestin EmaxBias Factor
nMnM
Salvinorin A3.63 (−8.29 ± 0.10)1036.67 (−8.18 ± 0.05)99.421
NaltrindoleAntagonistAntagonist
Diprenorphine0.960 (−9.02 ± 0.08)88.33.3 (−8.48 ± 0.14)87.02 G protein
Nalbuphine61.5 (−7.21 ± 0.11)81.347.2 (−7.33 ± 0.08)74.13 Arrestin
Butorphanol1.82 (−8.74 ± 0.07)94.31.70 (−8.77 ± 0.06)59.22 G protein
Cyclazocine1.19 (−8.92 ± 0.09)1020.806 (−9.09 ± 0.03)81.71
JDTicAntagonistAntagonist