TABLE 1

Pharmacokinetic parameters for plasma LVA in LCN and WT mice

Data from Fig. 3 were used for the determination of pharmacokinetic parameters, as described in Materials and Methods. Values represent means ± S.D. (n = 5 to 6).

StrainDoseTmaxCmaxt1/2AUC0–4hCL/F
mg/kgminμg/mlminmin ⋅µg/mlml/min
WT5027.4 ± 7.80.67 ± 0.1149.6 ± 10.056.5 ± 8.918.1 ± 3.0
LCN33.8 ± 10.61.30 ± 0.19*68.2 ± 14.7**154.5 ± 30.6*6.7 ± 1.4*
WT515.0 ± 00.067 ± 0.00827.4 ± 12.24.1 ± 1.129.1 ± 9.2
LCN20.0 ± 8.70.033 ± 0.004**26.7 ± 12.82.1 ± 0.4**49.4 ± 10.2
  • AUC, area under the curve.

  • * P < 0.01; **P < 0.05; compared with the corresponding WT group (Student’s t test).