Fast Inactivation (100 ms) | Intermediate Inactivation (1000 ms) | Recovery from Fast Inactivationa | |||||||
---|---|---|---|---|---|---|---|---|---|
V1/2 | k | n | V1/2 | k | n | τf | τs | n | |
mV | mV | mV | mV | ms | ms | ||||
Control | −46.4 ± 1.3 | 5.1 ± 0.3 | 7 | −51.0 ± 0.8 | −4.7 ± 0.1 | 4 | 6.5 ± 0.9 [80 ± 3%] | 127 ± 15 [20 ± 3%] | 5 |
Ranolazine (10 μM) | –51.6 ± 2.0* | 5.5 ± 0.2 | 7 | –59.0 ± 1.7** | −5.1 ± 0.2 | 4 | 8.1 ± 1.7 [73 ± 6%] | 380 ± 211 [27 ± 6%] | 5 |