TABLE 2

Biophysical parameters for fast inactivation

Fast Inactivation
(100 ms)Intermediate Inactivation
(1000 ms)Recovery from Fast Inactivationa
V1/2knV1/2knτfτsn
mVmVmVmVmsms
Control−46.4 ± 1.35.1 ± 0.37−51.0 ± 0.8−4.7 ± 0.146.5 ± 0.9 [80 ± 3%]127 ± 15 [20 ± 3%]5
Ranolazine (10 μM)–51.6 ± 2.0*5.5 ± 0.27–59.0 ± 1.7**−5.1 ± 0.248.1 ± 1.7 [73 ± 6%]380 ± 211 [27 ± 6%]5
  • a Values in brackets represent fractional amplitudes.

  • * P < 0.05; **P < 0.01.