TABLE 3

Affinity and potency values for morphinans using GloSensor and Tango assays

MorphinansG Protein EC50G Protein EmaxArrestin EC50Arrestin EmaxBias Factor
nMnM
Salvinorin A5.18 (−8.29 ± 0.10)99.75.75 (−8.24 ± 0.06)97.21
β-NNTA0.305 (−9.52 ± 0.12)97.00.268 (−9.57 ± 0.12)84.51
6′ GNTI4.74 (−8.32 ± 0.09)96.57.38 (−8.13 ± 0.12)34.76 G protein
5′ GNTIAntagonistAntagonist