TABLE 3

Biophysical parameters for slow inactivation

Slow Inactivation (10,000 ms)Recovery from Slow Inactivationa
V1/2kCnτfτsn
mVmVmsms
Control−40.4 ± 2.1−11.8 ± 0.755 ± 6621.7 ± 4.9 [36 ± 2%]817 ± 153 [64 ± 2%]6
Ranolazine (10 μM)–50.3 ± 3.0*−11.5 ± 0.938 ± 7***6151 ± 47* [43 ± 4%]2194 ± 449* [57 ± 4%]6
  • a Values in brackets represent fractional amplitudes.

  • * P < 0.05; ***P < 0.001.