ML213 dose-dependence parameters based on negative shift of activation curve and increase in maximal conductance for homomeric Kv7.4, Kv7.5, and heteromeric Kv7.4/7.5 channels
| Kv7 Isoforms | Gmax | EC50 Based on Gmax | │∆V0.5│ | EC50 Based on ∆V0.5 |
|---|---|---|---|---|
| % of Control | µM | mV | µM | |
| Kv7.4 | 212.3 ± 27.4 | 0.8 ± 0.3 | 25.0 ± 2.5 | 1.6 ± 0.2 |
| Kv7.5 | 180.7 ± 16.9 | 0.7 ± 0.2 | 43.9 ± 7.7* | 4.5 ± 2.0 |
| Kv7.4/7.5 | 204.8 ± 11.1 | 1.1 ± 0.6 | 34.2 ± 3.3 | 3.8 ± 1.2 |
↵* Significant difference from Kv7.4, Student’s t test, P < 0.05, n = 5.