Displacement of [3H]INCB3344 binding and [3H]CCR2-RA binding from CHO membranes expressing FLAG-tagged CCR2, CCR5, and CCR2-CCR5(C-term) receptors
Data are presented as mean pKD ± S.E.M. or mean KD (nM) of at least three experiments performed in duplicate.
| Construct | [3H]INCB3344 | [3H]CCR2-RA | ||
|---|---|---|---|---|
| CCR2 | 8.1 ± 0.1 | (8.3) | 8.8 ± 0.1 | (1.7) |
| CCR5 | no binding | 7.0 ± 0.1 | (100) | |
| CCR2-CCR5(C-term) | 8.6 ± 0.1 | (2.3) | 8.7 ± 0.1 | (2.0) |