TABLE 1
Kinetic parameters of inactivation for P4503A4 by ritonavir and a primary metabolite,
N-
ritonavir
K
I
k
inact
Partition Ratio
μM
min
−1
Ritonavir
0.59 ± 0.12
0.53 ± 0.05
19 ± 3
N-
Ritonavir
1.4 ± 0.3
0.33 ± 0.2
12 ± 2