Pharmacokinetic parameters of metformin in Oct3 knockout and wild-type mice
Oral bioavailability was obtained by dividing AUCoral by AUCIV. Each value represents the mean ± S.D. for four mice.
| Wild Type | Oct3 Knockout | |
|---|---|---|
| Intravenous Parameter | ||
| C0 (μg/ml) | 70.9 ± 11.7 | 148 ± 18.7** |
| AUC (min⋅μg/ml) | 2500 ± 257 | 5340 ± 775* |
| V (ml/kg) | 1480 ± 218 | 550 ± 60.3* |
| CL(ml/min per kg) | 18.6 ± 1.80 | 8.96 ± 0.85*** |
| Oral Parameter | ||
| Cmax (μg/ml) | 9.70 ± 0.77 | 11.2 ± 0.39 |
| AUC (min⋅μg/ml) | 1460 ± 184 | 1480 ± 44.5 |
| V/F (ml/kg) | 4240 ± 698 | 3670 ± 293 |
| CL/F (ml/min per kg) | 27.4 ± 2.25 | 28.0 ± 0.45 |
| F (AUC Oral/AUC IV) | 0.58 ± 0.09 | 0.27 ± 0.04 |
↵* P < 0.05, **P < 0.01, ***P < 0.001, significantly different from wild-type mice.