TABLE 1

Agonists and antagonists of the P2Y₁₄R

	Molecule	Potency
Natural agonists^{^a}	UDP-glucose	EC₅₀ = 132 nM
	UDP	EC₅₀ = 33 nM
Selective synthetic agonists^{^b}^,^{^c}	2-thio-UDP-glucose (MRS2690)	EC₅₀ = 49 nM
	α,β-methylene-2-thio-UDP (MRS2905)	EC₅₀ = 0.92 nM
Selective competitive antagonist^{^d}	PPTN	K_B = 400 pM

↵^a EC₅₀ values are from experiments measuring inhibition of cAMP accumulation in P2Y₁₄R-expressing CHO cells (Carter et al., 2009).
↵^b Values are from experiments measuring inositol phosphate accumulation in Cos-7 cells expressing the human P2Y₁₄R and Gα_q/i (Ko et al., 2007).
↵^c Values are from experiments measuring inhibition of cAMP accumulation in P2Y₁₄R-expressing HEK293 cells (Das et al., 2010).
↵^d K_B for PPTN was obtained in Schild analyses measuring antagonism of UDP-glucose–promoted inhibition of cyclic AMP accumulation in P2Y₁₄R-expressing CHO cells (Barrett et al., 2013).