TABLE 2

Biophysical parameters for M1585C and I1576C recovery from fast and slow inactivation

Results of fitting of eqs. 1, 2, and 3 to the data presented in Fig. 13. Parameters presented without S.E.M. were fixed during the curve-fitting procedure. Values during lidocaine exposure are compared to the same protocol under control conditions.

Prepulse Durationτ1τ2τ3A1A2A3n
msmsms
M1585C (Control)
 10 ms1.15 ± 0.081 ± 0.045
 50 ms1.13 ± 0.041000.84 ± 0.010.04 ± 0.0087
 10 s1.1332.78 ± 4.271035 ± 349.30.12 ± 0.030.57 ± 0.020.15 ± 0.025
 30 s1.1373.61 ± 14.111119 ± 2990.04 ± 0.020.61 ± 0.050.33 ± 0.058
M1585C (Lidocaine)
 10 ms1.9 ± 0.2**290 ± 34.30.49 ± 0.020.5 ± 0.014
 50 ms1.922.9 ± 8.182900.09 ± 0.030.22 ± 0.030.65 ± 0.027
 10 s1.9141.8 ± 18.81***1010 ± 353..80.04 ± 0.020.69 ± 0.07**0.24 ± 0.075
I1576C (Lidocaine)
 50 ms1.978.95 ± 10.32290 ± 34.30.16 ± 0.010.51 ± 0.040.31 ± 0.047
  • ** P < 0.01, ***P < 0.001.