TABLE 2

SPM-354 reverses S1P-induced RR interval augmentation and S1P-mediated CFR reduction in isolated perfused hearts of WT mice undergoing either normal ECG patterns or those displaying CHB

Baseline values were taken immediately following 5 minutes of heart equilibration from start of perfusion.

Treatment	Normal ECG		CHB
Treatment	RR Interval	CFR	RR Interval	CFR
	milliseconds	ml/min	milliseconds	ml/min
Baseline	177 ± 35	1.31 ± 0.31	168 ± 7.6	1.33 ± 0.40
+ S1P	351 ± 164^*	0.27 ± 0.15^*	620 ± 177^**	0.25 ± 0.05^*
+ SPM-354	156 ± 42^{^a}	1.32 ± 0.86^{^a}	205 ± 31^***	1.65 ± 0.54^{^a}

↵^a Not significant versus baseline.
↵* P < 0.05 versus baseline.
↵** P < 0.01 versus baseline.
↵*** P < 0.05 versus S1P.