TABLE 1

Uptake inhibition and release in rat brain synaptosomes

MDAMDMAMDDMAMDTMA
Uptake
 DAT (IC50 in nM) mean ± S.D.1177 ± 2521654 ± 2746010 ± 102833,300 ± 10,370
 NET (IC50 in nM) mean ± S.D.411 ± 49475 ± 338814 ± 174213,500 ± 2495
 SERT (IC50 in nM) mean ± S.D.384 ± 44227 ± 301661 ± 2892476 ± 491
Release
 DAT (EC50 in nM) mean ± S.D.50.1 ± 6.5125.6 ± 13.7InactiveInactive
 NET (EC50 in nM) mean ± S.D.59.1 ± 14.278.0 ± 15.8InactiveInactive
 SERT (EC50 in nM) mean ± S.D.141.2 ± 17.655.2 ± 6.7588.8 ± 68.0Inactive