TABLE 1

Summary of the effects of steroids on decay time course

The table shows weighted time constants (mean ± S.E.M.) under control conditions (no steroid) and in the presence of saturating concentrations (1–10 μM) of fourteen steroids. The single-channel open probability (Po) of receptors activated by 50 μM GABA in the absence (control) and presence of steroids is provided for comparison. Po was calculated from pooled intracluster open and closed time data published previously (Akk et al., 2004, 2005; Li et al., 2007a, 2009; Scaglione et al., 2008; Qian et al., 2014).

SteroidτwPo
ms
None (control)34 ± 30.41
3α5αP11O145 ± 160.93
3α5αP145 ± 250.84
3α5β17O94 ± 20.44
e18,19dinor3α5α16O53 ± 100.46
e18nor3α5α16O36 ± 20.49
e3α5β17O143 ± 150.72
3αCPP17βEp86 ± 90.83
3α5α17βEt86 ± 110.77
18nor3α5α17βCN77 ± 160.82
e3α5α4βOMe16O243 ± 240.86
3α5α17βCN132 ± 120.71
e19nor3α5α16O206 ± 360.58
e3α5α16O241 ± 210.84
3α5α16ene17Ph61 ± 100.50