Ligand | Free | Bound | Enzyme Ki ± S.D. | ||||
---|---|---|---|---|---|---|---|
nM | kcal/mol | kcal/mol | |||||
HA08 | −321.9 ± 2.5 | −23.9 ± 0.2 | −401.9 ± 0.7 | −43.1 ± 0.2 | 3.3 ± 0.8 | −11.6 ± 0.1 | −11.6 ± 0.5 |
Ang IV | −357.8 ± 1.6 | −37.9 ± 0.2 | −417.9 ± 5.1 | −66.6 ± 0.7 | 62.4 ± 17.5 | −9.8 ± 0.2 | −9.5 ± 1.0 |
Ang IV (γ-turn) | −346.0 ± 2.3 | −35.9 ± 0.3 | −409.6 ± 4.4 | −64.6 ± 0.8 | 62.4 ± 17.5 | −9.8 ± 0.2 | −10.2 ± 1.0 |
HA09 | −329.3 ± 1.4 | −25.1 ± 0.1 | −396.8 ± 1.3 | −42.9 ± 0.4 | 242.0 ± 72.0 | −9.0 ± 0.2 | −8.9 ± 0.4 |