TABLE 1

Saturation binding and dissociation kinetic rate constant (k_off) data for [³H]-QAW039 and [³H]-OC-459 binding to human CRTh2 receptors

Data are mean ± S.E.M. from at least three separate experiments.

Radioligand	Receptor Expression Level	Dissociation Kinetic Rate Constant k_off	Equilibrium Dissociation Constant K_d
	pmol mg⁻¹	min⁻¹	nM
[³H]-QAW039	6.26 ± 0.51	0.050 ± 0.006	1.14 ± 0.44
[³H]-OC-459	6.44 ± 0.06	2.80 ± 0.53	2.44 ± 0.58