CRTh2 Antagonist | cLogP | Log D7.4a | log KIAM7.4b | % Human Plasma Protein Unboundc | WBSC IC50 | ISC IC50 |
---|---|---|---|---|---|---|
nM | nM | |||||
QAW039 | 2.26 | 0.65 | 1.12 | 7.8 | 0.44 ± 0.19 | 0.40 ± 0.04 |
QAV680 | 1.15 | −0.34 | 0.55 | 21.4 | 31.0 ± 1.0 | 5.0 ± 1.0 |
AZD-1981 | 4.79 | 1.19 | 1.77 | 1.8 | 13.10 ± 4.03 | 2.21 ± 0.87 |
OC-459 | 4.57 | 1.32 | 1.91 | 0.5 | 422.5 ± 155.9 | 6.4 ± 1.4 |
BI-671800 | 4.58 | 1.65 | 1.95 | 0.4 | 104.9 ± 35.3 | 1.87 ± 0.88 |
Ramatroban | 3.97 | 1.34 | 1.89 | 2.7 | 195 ± 75.4 | 11.4 ± 1.9 |
Setipiprant | 4.28 | 1.35 | 1.88 | 0.4 | >500 | 10.7 ± 1.7 |