TABLE 1

X-ray structures of mammalian GDH reported in both the open and closed conformations

GDH	Ligands	PDB ID	Conformation	Resolution
WT	NADH + GLU + GTP	3MW9	Closed	2.4
WT	Glu, GTP, NADPH, and Bithionol	3ETD	Closed	2.5
WT	Glu, NADPH, GTP + GW5074	3ETG	Closed	2.5
WT	apo	1L1F	Open	2.7
WT	NADPH, glutamate, and GTP	1HWZ	Closed	2.8
WT	NADPH + GLU + GTP + Zinc	3MVQ	Closed	2.94
WT	NADPH, Glu, GTP, Hexachlorophene	3ETE	Closed	3
WT	NAD, PO4, and 2-oxoglutarate	1HWY	Closed	3.2
WT	NADPH + GLU + Eu	3MVO	Closed	3.23
R463A mutant	apo	1NR1	Open	3.3
WT	apo	1NR7	Open	3.3
WT	ADP	1NQT	Open	3.5
WT	NADPH and Epicatechin-3-gallate (Ecg)	3QMU	Open	3.62